Table 3.
Multivariate Cox proportional hazards analysis of overall survival in the TCGA HNSCC cohort.
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| HPV | <0.001 | 0.001 | ||
| Negative | Reference | Reference | ||
| Positive | 0.27 (0.13 to 0.50) | 0.28 (0.11 to 0.62) | ||
| Nodal status | 0.04 | 0.006 | ||
| N0 | Reference | Reference | ||
| N+ | 1.35 (1.01 to 1.82) | 1.56 (1.13 to 2.15) | ||
| Age, years old (range) 1 | 3.48 (1.38 to 8.86) | 0.008 | 3.44 (1.22 to 9.91) | 0.02 |
| DCBLD1, log2 RSEM (range) 1 | 3.97 (1.87 to 8.43) | <0.001 | 2.69 (1.09 to 6.58) | 0.03 |
| Smoking status | 0.30 | 0.24 | ||
| Never/previous < 10 PY 2 | Reference | Reference | ||
| Current/previous ≥ 10 PY 2 | 1.21 (0.86 to 1.74) | 1.26 (0.86 to 1.89) | ||
| Tumor size | 0.09 | 0.29 | ||
| T1-2 | Reference | Reference | ||
| T3+ | 1.31 (0.96 to 1.79) | 1.21 (0.85 to 1.73) | ||
| Gender | 0.02 | 0.43 | ||
| Female | Reference | Reference | ||
| Male | 0.70 (0.51 to 0.95) | 0.87 (0.62 to 1.24) | ||
| Anatomical subsite | 0.01 | 0.61 | ||
| Oropharynx | Reference | Reference | ||
| Oral tongue | 2.00 (1.16 to 3.64) | 0.83 (0.44 to 1.67) | ||
| Other oral cavity | 2.23 (1.35 to 3.97) | 0.92 (0.50 to 1.78) | ||
| Larynx and hypopharynx | 1.70 (0.98 to 3.12) | 0.71 (0.37 to 1.44) | ||
1 HR > 1 for numerical variables means that higher expression is associated with a worse overall survival. 2 Pack-year.