Table 1.

Genes regulated by 100 nM Ochratoxin A (OTA) in HEK293-T and HK-2 cells were enriched in DNA damage- and cell cycle-related pathways. Only the pathways having a significant adjusted p-value (−log(adjusted p-value) ≥ 1.3, equivalent to adjusted p-value ≤ 0.05) are displayed. The Z-scores correspond to the predicted regulation of the pathways (activation if Z > 0, inhibition if Z < 0), based on the log2 fold change of the genes enriched in the pathway (calculated by Ingenuity Pathway Analysis (IPA)). The Z-scores could not be computed for all pathways (lack of information concerning the impact of the regulation of some genes enriched in the concerned pathways). See also Figure S4 (Supplementary Materials).

IPA© Canonical Pathways	−log (Adjusted p-Value)	Z-Score
Nucleotide excision repair (NER) pathway	6.42	−1.789
Role of checkpoint (CHK) proteins in cell-cycle checkpoint control	2.49	−0.378
Role of breast cancer type 1 susceptibility (BRCA1) in DNA damage response	2.49	−0.378
Cell-cycle control of chromosomal replication	1.32	–
Hereditary breast cancer signaling	1.32	–