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. 2020 Jan 1;12(1):113. doi: 10.3390/cancers12010113

Figure 2.

Figure 2

Effect of PIC-loaded albumin nanoparticles on migration potential. Effect of PIC-loaded albumin NPs and free PIC on migration potential of CaCo-2 cell lines. The above image in (A) demonstrates the effect of free PIC and PIC-loaded albumin NPs on wound closure after 72 h of treatment. PIC-loaded albumin NPs demonstrate more void space than free PIC in the wound scratch of cell lines as compared to control and blank NPs. (B) depicts a significant variation of anti-migration activity of free PIC (p < 0.01) and PIC-loaded albumin NPs (p < 0.001) after 72 h of treatment at equal dose. Values are mean ± SEM with n = 3. ** p < 0.01, *** p < 0.001 compared with blank NPs. Similarly, (C,D) represents the effect of PIC-loaded albumin NPs and free PIC on migration potential of HT-29 cell lines. (C) shows the effect of free PIC and PIC-loaded albumin NPs on wound closure after 72 h of treatment. PIC-loaded albumin NPs demonstrate more void space than free PIC in the wound scratch of cell lines as compared to control and blank NPs. (D) shows a significant variation of anti-migration activity of free PIC (p < 0.01) and PIC-loaded albumin NPs (p < 0.001) after 72 h of treatment at equal dose. Values are mean ± SEM with n = 3. ** p < 0.01, *** p < 0.001 compared with blank NPs and ΔΔ p < 0.01 compared with the same dose of free PIC.