Table 3.
Estimated coefficients along with their 95% confidence intervals for distant metastasis.
| Coefficient | 95%-CI | p-Value | |||
|---|---|---|---|---|---|
| Lower | Upper | ||||
| Distant Metastasis | |||||
| Gender | Male | 1 | <0.001 | ||
| Female | 0.720 | 0.605 | 0.857 | ||
| Grading | G2 | 1 | <0.001 | ||
| G3 | 1.737 | 1.412 | 2.136 | ||
| Tumor size | 1.069 | 1.056 | 1.083 | <0.001 | |
| Margins | R0 | 1 | 0.006 | ||
| R1/R2 | 1.347 | 1.087 | 1.669 | ||
| Histology | Myxoid Liposarcoma | 1 | |||
| MPNST | 1.825 | 1.158 | 2.875 | 0.009 | |
| Myxofibrosarcoma | 1.064 | 0.750 | 1.508 | 0.729 | |
| Synovial Sarcoma | 1.986 | 1.343 | 3.976 | 0.001 | |
| UPS | 1.445 | 1.033 | 2.022 | 0.032 | |
| Angiosarcoma/Vascular Sarcoma | 2.016 | 1.022 | 3.797 | 0.043 | |
| Dedifferentiated/Pleomorphic Liposarcoma | 1.209 | 0.786 | 1.861 | 0.387 | |
| Leiomyosarcoma | 2.689 | 1.900 | 3.797 | <0.001 | |
| Other | 1.835 | 1.293 | 2.604 | 0.001 | |
| Neoadjuvant RTX | No | 1 | 0.005 | ||
| Yes | 1.351 | 1.097 | 1.663 | ||
| Restricted cubic spline 1 | 2.928 | 2.591 | 3.308 | <0.001 | |
| Restricted cubic spline 2 | 1.458 | 1.374 | 1.547 | <0.001 | |
| Restricted cubic spline 3 | 0.965 | 0.926 | 1.006 | 0.096 | |
| Restricted cubic spline 4 | 1.040 | 1.020 | 1.062 | <0.001 | |
| Restricted cubic spline 5 | 0.995 | 0.982 | 1.008 | 0.427 | |
| Restricted cubic spline for time-dependent effect of grading | 0.723 | 0.640 | 0.817 | <0.001 | |
| Constant | 0.108 | 0.078 | 0.149 | <0.001 | |
| Death | |||||
| Gender | Male | 1 | 0.864 | ||
| Female | 0.968 | 0.666 | 1.407 | ||
| Grading | G2 | 1 | 0.018 | ||
| G3 | 1.873 | 1.116 | 3.145 | ||
| Tumor size | 1.023 | 0.997 | 1.050 | 0.087 | |
| Margins | R0 | 1 | 0.198 | ||
| R1/R2 | 1.378 | 0.846 | 2.244 | ||
| Histology | Myxoid Liposarcoma | 1 | |||
| MPNST | 2.506 | 0.844 | 7.442 | 0.098 | |
| Myxofibrosarcoma | 3.136 | 1.325 | 7.418 | 0.009 | |
| Synovial Sarcoma | 0.600 | 0.150 | 2.416 | 0.472 | |
| UPS | 1.781 | 0.714 | 4.443 | 0.216 | |
| Angiosarcoma/Vascular Sarcoma | 11.165 * | 3.507 * | 35.542 * | <0.001 * | |
| Dedifferentiated/Pleomorphic Liposarcoma | 3.331 | 1.259 | 8.812 | 0.015 | |
| Leiomyosarcoma | 1.798 | 0.675 | 4.782 | 0.241 | |
| Other | 2.408 | 0.963 | 4.782 | 0.060 | |
| Neoadjuvant RTX | No | 1 | 0.048 | ||
| Yes | 0.541 | 0.295 | 0.993 | ||
| Restricted cubic spline 1 | 3.604 | 2.494 | 5.211 | <0.001 | |
| Restricted cubic spline 2 | 1.270 | 1.060 | 1.523 | 0.010 | |
| Restricted cubic spline 3 | 0.952 | 0.863 | 1.049 | 0.316 | |
| Restricted cubic spline 4 | 0.953 | 0.908 | 1.001 | 0.057 | |
| Restricted cubic spline 5 | 0.974 | 0.569 | 1.199 | 0.097 | |
| Restricted cubic spline for time-dependent effect of grading | 0.826 | 0.569 | 1.199 | 0.314 | |
| Constant | 0.010 | 0.004 | 0.025 | <0.001 | |
p-values in bold are considered statistically significant; CI = Confidence interval. RTX = radiotherapy. CTX = chemotherapy. UPS = undifferentiated pleomorphic sarcoma. * too few events.