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Structure of the main small-molecule inhibitors of HSP27 (blue), HSP70 (Green), and HSP110 (Orange). RP101 can inhibit HSP27 function via direct binding to Phe29 and Phe33. VER-155008 binds to the ATP-binding site at the N-terminus of HSP70. Pifithrin-µ inhibits specifically function of HSP70 via direct binding to its substrate binding domain. Compounds 52 and 33 bind to the ATP binding site at the N-terminus of HSP110.
