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. 2020 Jan 14;12(1):205. doi: 10.3390/cancers12010205

Figure 1.

Figure 1

A simplistic model of the mTOR signaling pathway in cervical cancer. Abbreviations: EIF: eukaryotic initiation factor, AMPK: adenosine monophosphate-activated protein kinase, PKCalpha: Protein kinase C-alpha, SGK1: serum and glucocorticoid-regulated kinase 1, 4EBP: Eukaryotic translation initiation factor 4E-binding protein 1, mTOR: mammalian target of rapamycin, SIN1: mammalian stress-activated protein kinase interacting protein 1, Rictor: Rapamycin-insensitive companion of mammalian target of rapamycin, mTORC1: rapamycin-sensitive mTOR-Raptor, mTORC2: rapamycin-insensitive mTOR-Rictor, mLST8: target of rapamycin complex subunit LST8, Raptor: regulatory-associated protein of mTOR, PRAS40: roline-rich Akt substrate of 40 kDa, PA: phosphatidic acid, PLD: phospholipase D, pRb: retinoblastoma protein, HPV: Human Papilloma Virus, PI3K: phosphoinositide 3-kinase, PDK1: Pyruvate Dehydrogenase Kinase 1, Akt: Protein kinase B, VEGF: Vascular endothelial growth factor, EGFR: epidermal growth factor receptor, TSC: Tuberous sclerosis 1.