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. 2020 Jan 17;12(1):229. doi: 10.3390/cancers12010229

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A). Epigenetic regulation of RASSF1A expression. DNA hypermethylation of the RASSF1A promoter mediated by DNMT1 and DNMT3 complexes associated with different proteins including MUC-1-ZEB1 and DAXX-p53 (left) and viral proteins (right). (B). Schematic of RASSF1A protein structure. RASSF1A contains different domains: C1/DAG (diacylglycerol), ATM (ataxia-telangiectasia mutated) domain, RA (Ras association) domain and SARAH (Salvador-Hippo-RASSF) domain. Several residues are phosphorylated (red) by the indicated kinases regulating the degradation of the RASSF1A protein and the mediation of different biological functions by this tumour suppressor.