Table 6.

Predicted LNA-i-miR-221 human PK parameters based on total CLp using different allometric approaches.

	Total Plasma Clearance	AUC/Dose	AUC for 0.78 ‡ mg/kg i.v. Dose	AUC for 1.82 ‡ mg/kg i.v. Dose	AUC for 5.0 ‡ mg/kg i.v. Dose
Allometric Method Used for Prediction	mL/min/kg	h·ng/mL·(mg Dose)−1	h·ng/mL	h·ng/mL	h·ng/mL
Direct scaling two-species (r, mk) (Equation (1a))	1.0	16,264	12,686	29,600	81,318
Tang et al. method two-species (r, mk) (Equation (3))	1.1	15,443	12,046	28,106	77,215
One-species (r) allometric scaling (Equation (4))	1.9	8643	6741	15,730	43,214
One-species (mk) allometric scaling (Equation (4))	1.4	11,711	9135	21,315	58,557
	Geometric mean	Geometric mean	Geometric mean	Geometric mean	Geometric mean
	1.3	12,627	9849	22,981	63,135

^‡ HED predicted according to Equation (2).