Table 8.
Protein binding values for the test item in human, monkey and rat plasma. Data are presented as mean ± standard deviation (n = 3). Unbound fraction (fu) values (averages of the two tested concentrations) used for the unbound clearance estimation.
| Species | LNA-i-miR-221 Concentration | |||
|---|---|---|---|---|
| 1 µM | 10 µM | Mean PPB | Mean fu | |
| Human | 98.6 ± 0.32 | 98.5 ± 0.09 | 98.55 | 0.0145 |
| Monkey | 98.2 ± 0.39 | 99.05 ± 0.39 | 98.63 | 0.0138 |
| Rat | 98.5 ± 0.17 | 98.9 ± 0.17 | 98.70 | 0.0130 |
PPB = plasma protein binding; mean fu = (100 − mean PPB%)/100.