. 2019 Dec 19;12(1):27. doi: 10.3390/cancers12010027

Table 10.

Rats’ individual PK parameters and the relative statistics.

Sex		λ	t_1/2	C₀	AUC_0–∞	AUC_0–∞/Dose	AUC Extrapolated	Vz	Cl
Sex		1/h	h	ng/mL	h·ng/mL	AUC_0–∞/Dose	%	mL/kg	mL/min/kg
F		0.174	3.99	43,094	23,980	1918	0.869	3000	8.7
		0.187	3.70	47,033	24,961	1997	0.603	2672	8.3
		0.187	3.70	64,272	31,455	2516	0.561	2120	6.6
	mean	0.183	3.80	51,467	26,799	2144	0.678	2597	7.9
	SD	0.008	0.168	11,264	4062	325	0.167	445	1.1
	CV%	4	4	22	15	15	25	17	0.2
M		0.178	3.90	49,251	24,364	1949	0.724	2890	8.6
		0.184	3.76	86,432	34,091	2727	0.490	1990	6.1
		0.175	3.95	44,593	23,120	1850	0.792	3083	9.0
	mean	0.179	3.87	60,092	27,192	2175	0.669	2654	7.9
	SD	0.005	0.099	22,930	6008	481	0.158	583	1.6
	CV%	3	3	38	22	22	24	22	0.3
M + F	mean	0.181	3.83	55,779	26,995	2160	0.673	2626	7.9
	SD	0.006	0.131	16,834	4592	367	0.145	465	1.2
	CV%	3	3	30	17	17	22	18	0.0