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. 2019 Dec 19;9(1):14. doi: 10.3390/cells9010014

Figure 2.

Figure 2

Identification of highly variable genes (HVGs). (A) The relationship between CV2 and mean expression of genes in LCL GM12878. The orange line shows the trend for the gamma GLM fit curve between CV2 and mean expression and used to identify HVGs. For each gene, the residual variability is calculated as the difference between observed CV2 and expected CV2 from the fitted curve. (B) Expression profiles of selected HVGs and lowly variable genes across cells. Cells are unsorted and remain a random order. Each vertical line is a cell, and the height of line indicates the level of gene expression in counts per million (CPM) in a cell.