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. 2019 Dec 19;9(1):14. doi: 10.3390/cells9010014

Table 2.

Shared HVGs identified in the three fibroblast samples: dermal, lung distal, and lung proximal, and the results of functional enrichment analysis.

Shared Highly Variable Genes (HVGs) Enriched GO Terms, Top 5 Enriched Reactome Pathways
ID3 MARCKSL1 DPT ID2 CYP1B1 IGFBP2 IGFBP5 APOD IGFBP7 SFRP2 PLK2 SOX4 PI16 CTGF SGK1 CITED2 IGFBP3 SERPINE1 TIMP1 OSR2 HAS2 MYC B4GALT1 PTGDS CRYAB BAMBI MFAP5 CSRP2 LUM PGF THBS1 FGF7 MT2A MT1X WISP2 ADAMTS1

  1. Collagen-containing extracellular matrix (GO:0062023)

  2. Extracellular matrix (GO:0031012)

  3. Epithelial cell proliferation (GO:0050673)

  4. Negative regulation of cell migration (GO:0030336)

  5. Extracellular matrix organization (GO:0030198)

  1. Extracellular matrix organization (R-HSA-1474244)

  2. Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs) (R-HSA-381426)