Giannini 1992.

Methods	Randomized allocation Double blind allocation and assessment Duration 6 months Sample size at entry: MTX 10 mg: 46 Placebo: 41
Participants	Patients with resistant JIA Mean age ‐ 10.4 Females ‐ 77% Concomitant use of steroids ‐ 33%
Interventions	Oral MTX 10 mg/m2/wk Study comparing 2 dosages (5 and 10 mg/m2/wk) ‐ only higher dose included
Outcomes	Joint range of motion Swollen joints Joints with pain on motion Physicians global
Notes	Quality score ‐ 5 Medication provided by Lederle Laboratories
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate