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. 2019 Dec 18;12(1):1. doi: 10.3390/cancers12010001

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene signature-derived risk score could identify high-risk patients in the pooled cohort. (A) Meta-analysis indicated that patients with higher risk scores exhibited worse prognosis compared to those with lower ones (HR = 4.84, 95% CI = 2.94–6.74) in the pooled cohort. Additionally, risk scores were normalized to Z-scores in each cohort, and we observed that (B) Z-scores of risk scores were significantly elevated in BCR patients compared with BCR-free (BCR-F) patients, especially in shorter-term BCR patients.