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. 2019 Dec 31;12(1):104. doi: 10.3390/cancers12010104

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Zoledronic acid–spherical polymeric nanoparticles’ (ZA-SPNs) physico-chemical properties. (A) Schematic of a ZA-SPN. DPPC: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DSPE-PEG: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinyl(polyethylene glycol)-2000]; PLGA: Poly(D,L-lactide-co-glycolic) acid. (B) SEM images of ZA-SPNs, showing their spherical shape and dimension (enlargement in the upper-right corner). Scale bar: 100 nm. (C) Size distribution of ZA-SPNs; polydispersity index (PDI) and ζ-potential values are also shown. (D) Size and PDI stability over time of ZA-SPNs. (E) ZA-SPNs batch average molarity (µM) obtained for different input amounts of ZA in the synthesis process, showing 300 μg as the best input condition. (F) Release profile of ZA from ZA-SPNs, showing the minimal ZA loss within the first 48 h. Panels C–F: mean values ± SD.