Table 1.

TLR7/8-activating microRNA (miRNA) candidates. Depicted are miRNA candidates enriched in the supernatant (log2FC ≥ ±1.0, p < 0.05) and miRNA candidates less present in neurons (log2FC > ±1.5, p < 0.05). miRNA family members are highlighted in grey. miRNAs contain hTLR8- and hTLR7/8-activating sequence motifs, as described by Forsbach et al. [4]. GU or AU content of individual miRNAs is given in %.

miRNA	Log2FC	p Value	Mature Sequence mirBASE 22.1	hTLR8	hTLR7/8	GU %	AU %
			Media
mmu-miR-128-1-5p	2.9	0.0005	CGGGGCCGUAGCACUGUCUGA			57.1	33.3
mmu-miR-128-2-5p	2.6	0.0198	GGGGGCCGAUGCACUGUAAGAGA			56.5	39.1
mmu-miR-6240	1.8	0.0363	CCAAAGCAUCGCGAAGGCCCACGGG			34.6	30.8
mmu-miR-340-3p	1.4	0.0001	UCCGUCUCAGUUACUUUAUAGC	UUAUA	UCUC	54.5	59.1
mmu-miR-129-2-3p	1.4	0.0316	AAGCCCUUACCCCAAAAAGCAU			22.7	54.5
mmu-miR-7068-3p	1.3	0.0363	UCACCCUGGACUGACUCUCAG			42.9	42.9
mmu-miR-132-5p	1.1	0.0391	AACCGUGGCUUUCGAUUGUUAC		UUUC UUGU	59.1	54.5
mmu-miR-137-3p	1.1	0.0410	UUAUUGCUUAAGAAUACGCGUAG	UUAUU		56.5	65.2
mmu-miR-181a-1-3p	1.1	0.0000	ACCAUCGACCGUUGAUUGUACC	GUAC	UUGU	45.5	50.0
mmu-miR-181b-5p	1.0	0.0373	AACAUUCAUUGCUGUCGGUGGGUU			66.7	54.2
mmu-let-7d-5p	1.0	0.0000	AGAGGUAGUAGGUUGCAUAGUU			68.2	59.1
mmu-let-7e-5p	1.0	0.0013	UGAGGUAGGAGGUUGUAUAGUU	UAUA	UUGU	77.3	59.1
			Neurons
mmu-miR-128-2-5p	−3.5	0.0000	GGGGGCCGAUGCACUGUAAGAGA			56.5	39.1
mmu-miR-128-1-5p	−2.8	0.0000	CGGGGCCGUAGCACUGUCUGA			57.1	33.3
mmu-miR-410-5p	−2.7	0.0072	AGGUUGUCUGUGAUGAGUUCG		UUGU	76.2	52.4
mmu-miR-409-5p	−2.7	0.0000	AGGUUACCCGAGCAACUUUGCAU			47.8	52.2
mmu-miR-124-5p	−2.6	0.0004	CGUGUUCACAGCGGACCUUGAU		UGUUC	54.5	45.5
mmu-miR-341-5p	−2.1	0.0051	CGGUCGGCCGAUCGCUCGGUC			57.1	23.8
mmu-miR-92a-1-5p	−1.9	0.0000	AGGUUGGGAUUUGUCGCAAUGCU		UUGU	69.6	52.2
mmu-miR-30f	−1.8	0.0051	GUAAACAUCCGACUGAAAGCUC			36.4	54.5