Table 4.
Characteristics of patients with and without distant metastases of prostate cancer.
| Parameter | Metastases (n = 19) | Local Tumor (n = 85) | p-Value |
|---|---|---|---|
| Number of CTCs (n): | |||
| CellCollector® | 1 (0–5) | 1 (0–7) | 0.524 |
| EPISPOT assay | 0 (0–2) | 1 (0–25) | 0.116 |
| CellSearch® system | 2.5 (0–569) | 0 (0–54) | <0.001 |
| Positive results (n): | |||
| CellCollector® (I) | 10 (52.6%) | 50 (58.8%) | 0.619 |
| EPISPOT assay (II) | 7 (38.9%) 1 | 45 (54.9%) 2 | 0.299 |
| CellSearch® system (III) | 11 (61.1%) 1 | 10 (14.3%) 3 | <0.001 |
| I + II + III | 18 (94.7%) | 72 (84.7%) | 0.457 |
| Age (years) | 67.8 ± 6.8 | 68.3 ± 6.4 | 0.791 |
| PSA (ng/mL) | 53.0 (0.6–164.0) | 28.4 (0.5–191.0) | 0.022 |
| PSA > 20 ng/mL (n) | 15 (78.9%) | 66 (77.6%) | 0.902 |
| Gleason sum (pts) | 8 (6–9) | 7 (6–9) | 0.004 |
| Gleason sum ≥ 8 pts (n) | 10 (52.6%) | 19 (22.4%) | 0.012 |
| cT > c (n) | 14 (73.7%) | 34 (40.5%) 4 | 0.011 |
| D’Amico criteria (n) | 2 (1–3) | 1 (1–3) | <0.001 |
Different group size than specified in the column header: 1 n = 18, 2 n = 82, 3 n = 70, 4 n = 84.