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. 2020 Jan 7;9(1):136. doi: 10.3390/cells9010136

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Domain structure of Munc13 proteins. All Munc13 isoforms share a conserved C-terminal priming unit and a central regulatory unit. Munc13-1 and ubMunc13-2 have a homologous N-terminal region containing an additional C2 domain. CaM-binding sites (dark green bars) are located in the regulatory unit. In bMunc13-2 and Munc13-3, another candidate CaM binding site (light green bars) was initially identified by computational methods, but found to be deficient of CaM-binding in the protein context [28]. C1 = diacylglycerol binding domain (yellow), C2 = Ca²⁺-binding/protein interaction domain (orange), MHD = Munc homology domain (red). The bMunc13-2 segments investigated in this study are displayed. Segment-A (aa 367–780), segment-B (aa 367–903), and segment-C (aa 703/704–742).