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. 2020 Jan 30;5(5):2345–2354. doi: 10.1021/acsomega.9b03735

Figure 1.

Figure 1

Concentration–time profile of complement C5a receptor 1 antagonists in wild-type mice following a single drug dose. Mice were administered a 1 mg/kg dose of PMX53 or PMX205 via intravenous (i.v.), intraperitoneal (i.p.), subcutaneous (s.c.), and per-oral (p.o.) routes. The concentration vs time profiles in plasma [(A), PMX53 and (B) PMX205], the brain [(C) PMX53 and (D) PMX205], and the spinal cord [(E) PMX53 and (F) PMX205] are shown. Dot points represent actual experimental values, and continuous lines represent predicted values generated by WINNONLIN (n = 4). Data are presented as mean ± SEM.