Table 1. Plasma Pharmacokinetic Parameters of Complement C5a Receptor 1 Antagonists^a.

		PMX53				PMX205
parameters	units	i.v.	s.c.	i.p.	p.o.	i.v.	s.c.	i.p.	p.o.
Cmax	μg/mL	17.42	3.77	4.92	0.25	34.62	5.62	5.95	0.77
Tmax	min		27.22	14.28	21.91		27.98	14.28	27.72
Vss	mL	2.90				2.76
V1_F	mL	1.72	<0.01	<0.01	0.05	0.87	<0.01	<0.01	0.01
CL_F	μL/min	199.16	0.11	0.16	2.01	146.90	0.07	0.13	0.52
V2_F	mL	1.05	<0.01	<0.01	<0.01	2.04	<0.01	<0.01	<0.01
CLD2_F	μL/min	84.57	<0.01	<0.01	<0.01	197.45	<0.01	<0.01	<0.01
K01	1/h		2.28	4.29	2.92		2.21	4.30	2.24
K10	1/h	6.94	2.13	4.11	2.56	10.17	2.08	4.10	2.09
K12	1/h	2.95	<0.001	<0.001	<0.001	13.67	<0.001	<0.001	<0.001
K21	1/h	4.85	2.14	2.00	2.58	5.82	2.08	2.00	2.09
K01_HL	min		18.28	9.70	14.23		18.85	9.67	18.55
K10_HL	min	5.99	19.47	10.10	16.22	4.09	19.93	10.13	19.85
Alpha	1/min	0.20	0.04	0.07	0.04	0.46	0.03	0.07	0.03
Beta	1/min	0.05	0.04	0.03	0.04	0.04	0.03	0.03	0.03
Alpha_HL	min	3.49	19.53	10.11	16.32	1.51	20.00	10.14	19.92
Beta_HL	min	14.73	19.42	20.75	16.02	19.33	19.92	20.75	19.87
MRT_last	min	13.21	38.77	27.43	32.61	19.74	40.71	24.78	37.68
MRT_INF_obs	min	18.03	47.94	36.15	33.97	37.00	64.30	26.30	54.41
MRT_INF_pred	min	17.92	48.13	36.08	34.07	37.29	64.29	26.34	54.19

^aCmax: peak plasma drug concentration; Tmax: time to reach peak plasma concentration following drug administration; Vss: apparent volume of distribution at a steady state; V1_F and V2_F: apparent volume of central and peripheral compartments in two compartmental models; CL_F and CLD2_F: apparent total body clearance of the drug from plasma and apparent total clearance of the drug from plasma after administration; K01: absorption rate constant; K10: elimination rate constant; K12 and K21: distribution and redistribution rate constant; K01_HL and K10_HL: distribution half-life and elimination half-life; Alpha and Beta: hybrid first-order rate constants expressing initial and terminal slopes of distribution and elimination phases; Alpha_HL and Beta_HL: initial or disposition half-life and terminal elimination half-life; MRT_last, MRT_INF_obs, and MRT_INF-pred: mean residence time at the last time point, infinity observed, and infinity predicted using two-compartmental analysis.