Table 6. Combined Yields and IC₅₀ Values for the Synthesized Donepezil Analogues.

^aR₂ = -S-α-phenylethyl. Reaction conditions: 10% Pd/C, 1 atm, H₂, THF, rt, 7–10 h.

^bCombined isolated yield.

^cIC₅₀ values are the mean of two separate experiments ± standard deviation. Each experiment was carried out in triplicate.

^dNot active in the concentration range tested in these experiments.

^eThis IC₅₀ value is the mean of three separate experiments.