Table 5.
Micellar patents issued in the area of cancer drug delivery (Adapted and modified from Mishra et al. [138]).
| Patent Type | Title | Patent No. | Chemical Formula | Action | Year | Inventor/Assignee |
|---|---|---|---|---|---|---|
| Micelles | C6-c18-acylated derivative of hyaluronic acid | WO2014082609 A1 | (HA)-[0(C:=O)NH-M]p | AC | 2014 | Contipro Biotech S.R.O. |
| Micelles | Polymer conjugated protein micelles | EP 2678001 A2 | PEG-Prolamine | AC | 2014 | South Dakota State University |
| Paclitaxel Micelle (NK105) | Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer | 09705599.0 | (poly(ethylene glycol)-copoly (L-aspartic acid) | AC | 2013 | Nanocarrier Co. Ltd. Nippon Kayaku Co., Ltd. |
| Nanoplatin® (NC-6004) | Pharmaceutical composition and combined agent | 098101554 | (poly(ethylene glycol)-copoly (amino acid) | AC | 2013 | TOUDAI TLO Ltd. |
| DACH-Platin Micelle (NC-4016) | Coordination compound composed of diaminocyclohexane platinum (Ii) and block copolymer | 2007-520209 | (poly(ethylene glycol)-copoly (amino acid) | AC | 2013 | The University of Tokyo |
| Protein Micelle | Electrostatic bonding type macromolecular micelle drug carrier | EP2583563 A1 | polyethylene glycol and poly(α,-β -aspartic acid) | AC | 2013 | TOUDAI TLO Ltd. |
| siRNA Micelle | Polyethylene glycol/polycation block copolymer | EP2087912 A1 | PEG-PLys | AC | 2013 | The University of Tokyo |
| Sensor Linked Micelle | Active targeting polymer micelle encapsulating drug, and pharmaceutical composition | 2008-539901 | poly(ethylene glycol)-b-poly(2-aminoethyl methacrylate)-b-poly(styrene) | AC | 2013 | Nanocarrier Co. Ltd. |
| pH-Sensitive Micelle | Novel block copolymer used for preparing pH-responsive polymer micelles | 2009-7007877 | [PEG-p(Asp-Hyd-Adr)] | AC | 2013 | The University of Tokyo |
| Docetaxel Micelle | Docetaxel polymer derivative, method for producing same and use of same | 2009250393 | (mPEG-PDLLA) | AC | 2013 | Nanocarrier Co. Ltd. |
| Bortezomib Micelle | Pharmaceutical composition that includes block copolymer containing boronic acid compound | EP 2692777 A1 | polyethylene glycol-polyglutamic acid | AC | 2013 | Nanocarrier Co. Ltd. |
| Micelles | Micelles for the solubilisation of gossypol | 20120321715 | Poloxamer or PEG-PCL | AC | 2012 | Wisconsin Alumni Research Foundation., US |
Abbreviations: AC (Anticancer activity including ovarian cancer and various cancers such as lung and prostate cancer), MA Microaggregates), PEG/PEG 2000 (poly(ethylene glycol-2000), Hyaluronic acid (HA), C = O (carbonyl group), -PLys (polylysine), Asp(Aspartate), Hyd-Adr(hydrazone Adriamycin, poly-DL-lactide (PDLLA), PCL(polycaprolactone).