Table 2.
Haplotype structures and frequencies in the IL-10 gene promoter
| Subjects | N | GCC | ACC | GTA | ATA | GCA |
|---|---|---|---|---|---|---|
| PEX, n (%) | 114 | 82 (71.9)a | 16 (14) | 10 (8.8) | 6 (5.3) | 0 (0) |
| Control, n (%) | 126 | 118 (93.6) | 4 (3.2) | 2 (1.6) | 0 (0) | 2 (1.6) |
| p-value | Ref. group | 0.02 | 0.08 | 0.07 | 0.51 | |
| OR (95% CI) | – | 5.76 (5.17–24.49) | NA | NA | NA | |
| PEXG, n (%) | 118 | 86 (72.9) | 22 (18.6) | 8 (6.8) | 2 (1.7) | 0 (0) |
| Control, n (%) | 126 | 118 (93.7) | 4 (3.2) | 2 (1.6) | 0 (0) | 2 (1.6) |
| p-value | Ref. group | 0.006 | 0.16 | 0.42 | 0.51 | |
| OR (95% CI) | – | 7.54 (6.62–30.76) | NA | NA | NA | |
| POAG, n (%) | 114 | 80 (70.2) | 22 (19.3) | 10 (8.8) | 2 (1.8) | 0 (0) |
| Control, n (%) | 126 | 118 (93.7) | 4 (3.2) | 2 (1.6) | 0 (0) | 2 (1.6) |
| p-value | Ref. group | 0.003 | 0.08 | 0.41 | 0.51 | |
| OR (95% CI) | – | 8.11 (7.13–33.15) | NA | NA | NA |
a Numbers of haplotypes are shown with their frequencies in parentheses. Constituents of the haplotypes are written in the order of −1082 G/A, −819 C/T and – 592 C/A SNPs of IL-10