Fig. 5.

Hsa_circ_0011385 promoted thyroid cancer cell proliferation and suppressed cell cycle arrest by miR-361-3p. BCPAP cells were transfected with miR-361-3p mimics and/or hsa_circ_0011385 plasmid, respectively. a miR-361-3p expression was determined by qRT-PCR assay in each group (**P < 0.01 vs. NC group, ^#P < 0.05 vs. mimics group). b Bax, caspase-3, TIMP, MMP2, and MMP9 expression levels were measured by Western blot assay in each group. GAPDH was used as an internal reference. c Cell viability was evaluated by CCK-8 assay in each group (**P < 0.01 vs. NC group, ^#P < 0.05 vs. mimics group). d The proliferation abilities of BCPAP cells transfected with miR-361-3p mimics and/or hsa_circ_0011385 plasmid was detected by CFSE assay (**P < 0.01 vs. NC group, ^#P < 0.05 vs. mimics group). e Flow cytometry was performed to examine the cell cycle distribution in each group (*P < 0.05 vs. NC group, ^#P < 0.05 vs. mimics group)