Table 1.
Clinical, pathological and molecular characteristics of the study groups
| N | MITF+ N (%) | MITF− N (%) | ORa | Lower CI | Upper CI | p-value | ||
|---|---|---|---|---|---|---|---|---|
| Phototype | 927 | I | 0 (0) | 52 (6) | 0.27 | |||
| II | 15 (75) | 478 (53) | ||||||
| III | 5 (25) | 353 (39) | ||||||
| IV | 0 (0) | 24 (3) | ||||||
| Freckles | 349 | None | 8 (4) | 77 (23) | 0.37 | |||
| Rare | 4 (2) | 126 (38) | ||||||
| Few | 7 (35) | 89 (27) | ||||||
| Many | 1 (5) | 37 (11) | ||||||
| Hair color | 932 | Albino | 0 (0) | 1 (0) | 0.06 | |||
| Red | 1 (5) | 49 (5) | ||||||
| Blond | 9 (43) | 201 (22) | ||||||
| Blond_red | 0 (0) | 9 (1) | ||||||
| Brown | 7 (33) | 565 (62) | ||||||
| Black | 4 (19) | 86 (9) | ||||||
| Eye color | 931 | Light blue | 7 (37) | 214 (23) | 0.50 | |||
| Blue | 1 (5) | 38 (4) | ||||||
| Green | 2 (11) | 98 (11) | ||||||
| Grey | 0 (0) | 21 (2) | ||||||
| Light brown | 1 (5) | 206 (23) | ||||||
| Dark brown | 8 (42) | 324 (36) | ||||||
| Black | 0 (0) | 5 (1) | ||||||
| Hazel | 0 (0) | 6 (1) | ||||||
| Number of nevi | 492 | < 10 | 3 (17) | 200 (42) | 0.04 | |||
| 10–50 | 10 (55) | 185 (39) | ||||||
| > 50 | 5 (28) | 89 (19) | ||||||
| Histologically diagnosed Dysplastic nevi | 866 | Median (IQR) | 0 (0–1) | 0 (0–0) | < 0.001 | |||
| 0 | 10 (50) | 769 (91) | 9.93 | 3.59 | 27.53 | < 0.001 | ||
| 1+ | 10 (50) | 77 (9) | ||||||
| Familial | 984 | Spo | 17 (77) | 833 (87) | 1.9 | 0.54 | 5.48 | 0.21 |
| Fam | 5 (23) | 129 (13) | ||||||
| Age at first melanoma | 858 | Median (IQR) | 44 (32.25–58.75) | 49 (38.99–61.71) | 0.20 | |||
| N. of melanomas removed | 983 | Median (IQR) | 1 (1–1.75) | 1 (1–1) | 0.02 | |||
| 1 | 16 (73) | 855 (89) | 3.02 | 0.95 | 8.35 | 0.03 | ||
| 2+ | 6 (27) | 106 (11) | ||||||
| Breslow mm | 930 | Median (IQR) | 1 (0.6–2.025) | 1 (0.35–1.765) | 0.22 | |||
| Sentinel node | 337 | Neg | 6 (27) | 266 (28) | 1.41 | 0.14 | 8.1 | 0.65 |
| Pos | 2 (9) | 63 (7) | ||||||
| Stage | 771 | IS | 2 (17) | 122 (16) | 0.65 | |||
| I | 8 (67) | 473 (62) | ||||||
| II | 2 (17) | 75 (10) | ||||||
| III | 0 (0) | 56 (7) | ||||||
| IV | 0 (0) | 33 (4) | ||||||
| Pancreatic cancer in family | 972 | No | 19 (86) | 901 (94) | 2.90 | 0.53 | 10.35 | 0.11 |
| Yes | 3 (14) | 49 (5) | ||||||
| Kidney cancer in family | 971 | No | 18 (82) | 910 (95) | 5.17 | 1.21 | 16.74 | 0.01 |
| Yes | 4 (18) | 39 (5) | ||||||
| Site of first melanoma | 943 | Head and neck | 1 (5) | 74 (8) | 0.27 | |||
| Trunk | 8 (40) | 464 (50) | ||||||
| Arms | 6 (30) | 125 (14) | ||||||
| Legs | 5 (25) | 260 (28) | ||||||
| Histotype of first melanoma | 722 | Acral | 2 (9) | 11 (2) | 0.04 | |||
| Lentigo maligna | 0 (0) | 36 (5) | ||||||
| Nodular | 7 (32) | 132 (19) | ||||||
| SSM | 13 (59) | 454 (64) | ||||||
| Other | 0 (0) | 67 (10) | ||||||
| MC1R | 576 | –/– | 6 (30) | 165 (30) | 0.45 | |||
| r/– | 4 (20) | 158 (28) | ||||||
| r/r | 2 (10) | 24 (4) | ||||||
| R/– | 6 (30) | 111 (21) | ||||||
| R/r | 1 (5) | 74 (13) | ||||||
| R/R | 1 (5) | 24 (4) |
Significant p-values are italicized
N = number of patients, % = percentage of patients, OR = odds ratio, lower CI = lower confidence interval limit, upper CI = upper confidence interval limit, IQR = inter-quartile range, Spo = sporadic, Fam = familial, Neg = negative, Pos = positive, SSM = superficial spreading melanoma, IS = in situ melanoma, R = MC1R red hair color variant, r = MC1R non-red hair color variant
aOdds that the outcome occurs in the MITF+ group compared to the odds of the outcome occurring in the MITF− group