Table 2.
Risk factors for PCOS
| Risk factor | Genotype | Cases N = 55 | Controls N = 110 | Crude OR (95% CI) | Adjusted OR (95%CI) Model a |
|---|---|---|---|---|---|
| BMI (mean, SE) | – | 26.89 ± 0.72 | 25.25 ± 0.34 | 1.1 (1.01–1.18) | 1.1 (1.01–1.2) |
| Serum testosterone (mean, SE) | – | 4.713 ± 0.46 | 3.415 ± 0.26 | 1.2 (1.03–1.29) | |
| Serum kisspeptin (mean, SD) | – | 4.873 ± 0.24 | 4.127 ± 0.13 | 1.37 (1.1–1.71) | 1.4 (1.14–1.85) |
|
FTO (rs9939609) (No, %) |
AA | 22 (40%) | 15 (13.6%) | 4.9 (2.16–11.0) | 5.7 (2.41–13.63) |
| AT | 13 (23.6%) | 23 (20.9%) | 2.0 (0.86–4.65) | 2.2 (0.9–5.35) | |
| TTR | 20 (36.3%) | 72 (65.4%) | 1 |
aLogistic Regression (LR) model showing adjusted odds ratio (OR) of factors significant for PCOS
Logistic regression analysis was carried out for all the SNPs of Kiss1, GPR54, GnRH, FSHB, FSHR, LHCGR, INSR and FTO along with hormonal (kisspeptin and testosterone levels) characteristics. Only the variables with significant association are shown in the table