Table 3.
Association between FTO SNP (rs9939609) and PCOS risk under multiple models of inheritance
| Model | Genotype | Controls | Cases | OR (95% CI) | p | AIC | BIC |
|---|---|---|---|---|---|---|---|
| Codominant | T/T | 68 (65.4%) | 20 (37%) | 1.00 | 0.00 | 192.7 | 201.8 |
| A/T | 23 (22.1%) | 13 (24.1%) | 1.92 (0.83–4.47) | ||||
| A/A | 13 (12.5%) | 21 (38.9%) | 5.49 (2.34–12.88) | ||||
| Dominant | T/T | 68 (65.4%) | 20 (37%) | 1.00 | 0.00 | 195.3 | 201.4 |
| A/T-A/A | 36 (34.6%) | 34 (63%) | 3.21 (1.62–6.37) | ||||
| Recessive | T/T-A/T | 91 (87.5%) | 33 (61.1%) | 1.00 | 0.00 | 192.9 | 199 |
| A/A | 13 (12.5%) | 21 (38.9%) | 4.45 (2.01–9.90) | ||||
| Overdominant | T/T-A/A | 81 (77.9%) | 41 (75.9%) | 1.00 | 0.78 | 206.9 | 213 |
| A/T | 23 (22.1%) | 13 (24.1%) | 1.12 (0.51–2.43) | ||||
| Logadditive | – | – | – | 2.30 (1.51–3.51) | 0.00 | 190.9 | 197 |
OR odds ratio, CI confidence interval, AIC Akaike information criteria, BIC Bayesian information criteria