Comparison 17. Amoxycillin versus penicillin.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Nasopharyngeal aspirates for S. pneumoniae	1	1486	Odds Ratio (M‐H, Random, 95% CI)	0.90 [0.72, 1.13]
2 Age less than 1 year	1	1702	Odds Ratio (M‐H, Random, 95% CI)	1.06 [0.87, 1.29]
3 Male sex	2	1905	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.87, 1.25]
4 Weight below 2 Z score (indicating severe malnutrition)	1	1686	Odds Ratio (M‐H, Random, 95% CI)	0.92 [0.70, 1.19]
5 Breast fed	1	1702	Odds Ratio (M‐H, Random, 95% CI)	1.12 [0.92, 1.37]
6 Received antibiotics in last 7 days	2	1905	Odds Ratio (M‐H, Random, 95% CI)	0.97 [0.69, 1.38]
7 Failure rate at 48 hours	1	1702	Odds Ratio (M‐H, Random, 95% CI)	1.03 [0.81, 1.31]
8 Failure rate on day 5	2	1905	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.58, 2.30]
9 Failure rate on day 14	1	1702	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.84, 1.29]
10 Death rates	2	1905	Odds Ratio (M‐H, Random, 95% CI)	0.07 [0.00, 1.18]
11 Nasopharyngeal H. influenzae	1	1482	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.78, 1.29]
12 Respiratory syncytial virus (RSV) in nasopharyngeal swabs	2	1731	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.83, 1.31]
13 Mean age	1	203	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
14 Blood culture positive for S. pneumoniae	1	203	Odds Ratio (M‐H, Random, 95% CI)	0.34 [0.03, 3.29]
15 Failure rate on day 5 in radiographically confirmed pneumonia	1	203	Odds Ratio (M‐H, Random, 95% CI)	2.36 [0.59, 9.39]