Aurangzeb 2003.
Methods | Randomised, non‐blinded controlled clinical trial | |
Participants | Children between 3 to 72 months of age, admitted in the hospital with community‐acquired pneumonia | |
Interventions | The patients were randomly allotted to 1 of the 3 groups Group 1 was given amoxycillin 75 mg/kg/d IV in 3 divided doses, Group 2 was given cefuroxime 75 mg/kg/d IV in 3 divided doses and Group 3 was given clarithromycin 15 mg/kg/d IV divided into 2 divided doses | |
Outcomes | 1. Improvement defined as slower respiratory rate (either back to normal for the age of the child), or more than 5 as compared to the previous day evaluation without retractions. The same defined as still breathing fast as before as or higher than that with no chest in drawing or danger signs 2. Worse was defined as development of severe pneumonia or very severe disease 3. Cure was defined as return of respiratory rate to age specific normal range |
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Notes | — | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | No information provided |
Allocation concealment (selection bias) | Unclear risk | No information provided |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Open‐label study |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Open‐label study |
Selective reporting (reporting bias) | Unclear risk | There are discrepancies in the number of patients in different study arms |
Incomplete outcome data (attrition bias) All outcomes | Low risk | None |
Other bias | Unclear risk | Source of funding not mentioned |