| Methods |
RCT comparing amoxycillin and co‐trimoxazole in non‐severe pneumonia |
| Participants |
Children 2 to 59 months with non‐severe pneumonia |
| Interventions |
PO amoxycillin 25 mg/kg/day for 5 days or co‐trimoxazole 20/4 mg/kg/day for 5 days |
| Outcomes |
Cure rate, failure rate, change of antibiotics |
| Notes |
Blinded, exclusion criteria: severe pneumonia, very severe disease, chronic illness, past history of 2 or more episodes of wheeze, acute bronchial asthma, antibiotics in past 48 hours |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Random numbers generated using a computer program |
| Allocation concealment (selection bias) |
Low risk |
The drug assignment was concealed from patients parents and study personnel |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Double‐blind randomised controlled trial |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Double‐blind randomised controlled trial |
| Selective reporting (reporting bias) |
Low risk |
No selective reporting |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Incomplete data adequately addressed |
| Other bias |
Low risk |
Funded by World Health Organization |
