| Methods |
RCT comparing ampicillin in combination with penicillin with chloramphenicol for pneumonia diagnosed by clinical/radiological evidence |
| Participants |
Children 5 months to 4 years with pneumonia admitted to hospital |
| Interventions |
IM/IV ampicillin (100 mg/kg/day) for 48 hours than PO, IV penicillin (100,000 IU/kg/day) plus chloramphenicol (100 mg/kg/day) |
| Outcomes |
Cure rate, failure rate |
| Notes |
Not blinded. Exclusion criteria: acute bronchiolitis, allergy to penicillin, antibiotics in past 2 days, other drugs by treating physician receiving anti‐tuberculosis drugs |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer‐generated random listen |
| Allocation concealment (selection bias) |
Unclear risk |
Information not provided |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Open‐label study |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Open‐label study |
| Selective reporting (reporting bias) |
Unclear risk |
Data not completely described |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
No intention‐to‐treat analysis and details of excluded patients not clear |
| Other bias |
Unclear risk |
Source of funding not mentioned |
