| Methods |
RCT comparing procaine penicillin and amoxycillin for radiographically confirmed pneumonia |
| Participants |
Children aged 6 months to 18 years with pneumonia |
| Interventions |
PO amoxycillin (50 mg/kg/day) or procaine penicillin IM (50,000 IU/kg/day) |
| Outcomes |
Hospitalisation rate, failure rate, temperature more than 38.5 °C, ill appearance, increased respiratory rate |
| Notes |
Unblinded
Exclusion criteria: chronic illness, asthma, sickle cell disease, cystic fibrosis, allergy to amoxycillin, or penicillin, antibiotics in past 1 week, wheezing, concurrent febrile illness |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Sequence generation not mentioned |
| Allocation concealment (selection bias) |
Low risk |
Sealed envelope opened by Emergency Department nurse |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Open‐label study |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Open‐label study |
| Selective reporting (reporting bias) |
Low risk |
No selective reporting |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Incomplete data adequately addressed |
| Other bias |
Unclear risk |
Source of funding not mentioned |
