Wubbel 1999.
| Methods | RCT comparing azithromycin and erythromycin in children over 5 years of age with pneumonia; and comparing azithromycin with co‐amoxyclavulanic acid in children under 5 years of age | |
| Participants | Children aged between 6 months a 16 years with pneumonia | |
| Interventions | PO azithromycin (10 mg/kg on day 1 followed by 5 mg/kg/day for next 4 days) or co‐amoxyclavulanic acid 40 mg/kg/day for 10 days in children under 5 years of age; and erythromycin 40 mg/kg/day for 10 days in children over 5 years | |
| Outcomes | Clinically diagnosed cure rates, failure rates and improvement | |
| Notes | Non‐blinded. Exclusion criteria: hypersensitivity to study drugs, nosocomial pneumonia, hospitalisation, antibiotics in last 7 days | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Details not mentioned |
| Allocation concealment (selection bias) | Unclear risk | Allocation concealment not clearly described |
| Blinding of participants and personnel (performance bias) All outcomes | High risk | Unblinded study |
| Blinding of outcome assessment (detection bias) All outcomes | High risk | Unblinded study |
| Selective reporting (reporting bias) | Low risk | No selective reporting |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Incomplete data adequately addressed |
| Other bias | Unclear risk | Funded by Pfizer Inc. |
bd: twice a day CHD: congenital heart disease CPZ: carbamazepine IM: intramuscular IV: intravenous LRTI: lower respiratory tract infection PO: orally PTV: post‐therapy visit q6h: every 6 hours q8h: every 8 hours q12h: every 12 hours RCT: randomised controlled trial Sp02: oxygen saturation TB: tuberculosis tds: three times a day TOCV: test of cure visit WHO: World Health Organization