Comparison 12. Distant metastases.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Distant metastases, colorectal	7	1853	Odds Ratio (M‐H, Fixed, 95% CI)	1.01 [0.76, 1.34]
2 Distant metastases, colon	4	938	Odds Ratio (M‐H, Fixed, 95% CI)	0.82 [0.55, 1.22]
3 Distant metastases, rectum	3	578	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.66, 2.05]
4 Lung	2	317	Odds Ratio (M‐H, Fixed, 95% CI)	1.19 [0.29, 4.94]
5 Liver	2	317	Odds Ratio (M‐H, Fixed, 95% CI)	0.95 [0.33, 2.69]