| Methods |
RCT
Single surgeon
Sample size calculation
Follow up (
Intention to treat
Number of patients not randomised unclear
Preoperative randomisation
Conversion rate 3%
Intention to treat
Follow‐up 40 months (median) |
| Participants |
n=269
Inclusion criteria: left‐sided primary colon cancer that requires the mobilisation of the splenic flexure, TNM stage II or III, curative and elective surgery, ASA I‐III, age>18 yrs
Exclusion criteria: Cecal. ascending, proximal transverse, middle and distal sigmoid and rectal cancer; emergency or palliative surgery, evidence of disseminated disease or adjacent organ invasion, tumor> 8 cm in diameter, BMI >40 kg/m2, previous major upper abdominal surgery |
| Interventions |
Laparoscopic versus open
Tumour location: distal transverse colon, splenic flexure, descending colon, S‐D junction, proximal sigmoid colon
Adj. therapy: postoperative chemotherapy in stage III patients
Type of resection: (extended) left‐sided hemicolectomy |
| Outcomes |
Adjuvant therapy, type of resection, localisation of the tumor, tumor stage, number lymph nodes harvested, duration of follow‐up, local recurrence, distant metastases. |
| Notes |
Halpern and Preston
quality score:
18 out of 22 |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
