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. Author manuscript; available in PMC: 2020 Nov 8.
Published in final edited form as: Circ Res. 2019 Oct 8;125(11):1006–1018. doi: 10.1161/CIRCRESAHA.119.315348

Figure 2. Mice heterozygous for SMC-specific deletion of Eln show cardiovascular remodeling similar to Eln+/− mice, but have normal blood pressure.

Figure 2.

(A) H&E and VVG staining of P18 ascending and (B) P12 descending aorta show the elastic laminae structure. Scale bar = 50 μm. Average number of elastic laminae (EL) are shown below the images. * = P < 0.05 between genotypes for each artery by two-way ANOVA with Sidak’s multiple comparisons test. N = 4-5/group. (C) Reduced arterial diameter (top) and compliance (bottom) in P30 male Sm22aCre;Elnf/+ common carotid artery is similar to Eln+/−. N = 8/group. (D) Unlike Eln+/− mice, Sm22aCre;Elnf/+ mice do not have increased systolic blood pressure. Heart rate is similar across groups. N = 6-8/group. For C and D, * and # indicate P < 0.05 compared to Eln+/+ for Sm22aCre;Elnf/+and Eln+/−, respectively, by one-way ANOVA with Sidak’s multiple comparisons test. Sm22aCre;Eln+/+ were not significantly different from Eln+/+. Mean ± SD.