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. Author manuscript; available in PMC: 2020 Nov 8.
Published in final edited form as: Circ Res. 2019 Oct 8;125(11):1006–1018. doi: 10.1161/CIRCRESAHA.119.315348

Figure 6. Electron microscopy of the IEL in SMC- and EC-specific Eln knockouts.

Figure 6.

(A) The IEL in the ascending aorta of P8 Elnf/f mice is intact (arrowhead), while in some regions it is composed of small aggregates of elastin that never fused to form a continuous barrier in Sm22aCre;Elnf/f mice (arrow). (B) In regions where the IEL is thicker and more intact in Sm22aCre;Elnf/f ascending aorta, it has a moth eaten appearance (arrow). (C) In contrast, the descending aorta in P8 Elnf/f and Sm22aCre;Elnf/f mice has an intact IEL (arrowheads). (D) The IEL is also intact in the ascending aorta of P10 Elnf/+ and Tie2Cre;Elnf/f mice (arrowheads). All scale bars = 10 μm.