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. 2020 Feb 6;13:14. doi: 10.3389/fnmol.2020.00014

Table 1.

Overview of transient analysis methods.

Temporally-defined transient Non-parametric Single mean comparison? Exact p value* Range estimate Pros Considerations
Summary analyses
AUC × Possible Possible • Simple
  • Undefined extent/location of transient

  • Jittered transient still detected

  • Issues with defining analysis window

Features (peak dF, peak frequency) × Possible × Possible
  • Intuitive

  • Analysis of various features

  • Requires a comparison period

  • Issues with defining analysis window

Waveform analyses
t interval × ✓* • Simple • Parametric assumption
Bootstrap interval ×*
  • Powerful

  • Few assumptions

  • Computationally demanding compared to tCI

  • Percentile interval does not inherently control per comparison Type I error rate at α

Permutation tests × ✓* × • Conservative
  • Lowest power of methods considered

  • Computationally demanding compared to tCI

  • Requires a comparison distribution

  • Distribution difference only —cannot directly indicate parameter range/direction

*Per comparison p value—diverges from alpha when using consecutive thresholds. Note. AUC, area under the curve; tCI, t interval.