Table 2. Multiple HPVmHNSCC Identified from SEER database.
Patients with multiple HPVmHNSCC with at least one tumor located in the oropharynx were found tc be more likely to present with early T, N and overall stage than single HPVmHNSCCs. When two numbers are included, separated with a "/". The first number represents the number of patients, and the second number represents the number of tumors.
| HNSCC (n=18075/18108) |
HPVmHNSCC (n=6273/6306) |
Single HPVmHNSCC (n=6240) |
HPVmHNSCCs with second primary (HPV status positive or unknown) (n=60/120) |
Multiple HPVmHNSCCs (n=32/64) |
Single vs multiple HPVmHNSCC p-values |
|
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male | 14575 (80.6) | 5408 (86.2) | 5377 (86.2) | 54 (90) | 29 (90.6) | 0.6123 |
| Female | 3501 (19.4) | 866 (13.8) | 863 (13.8) | 6 (10) | 3 (9.4) | 0.6123 |
| Age | ||||||
| mean | 62.0 | 60.6 | 60.6 | 59.9 | 56.7 | 0.0249 |
| median | 61.0 | 60.0 | 60 | 59.0 | 55.5 | n/a |
| range | 18-103 | 18-95 | 18-95 | 39-82 | 39-81 | n/a |
| Race | ||||||
| White | 14804 (81.9) | 5646 (90) | 5616 (90) | 55 (91.7) | 28 (87.5) | 0.5558 |
| Black | 1771 (9.8) | 338 (5.4) | 335 (5.4) | 4 (6.7) | 3 (9.4) | 0.2467 |
| Japanese | 96 (0.5) | 26 (0.4) | 25 (0.4) | 1 (1.7) | 1 (3.1) | 0.1284 |
| Other | 1299 (7.2) | 231 (3.7) | 231 (3.7) | 0 (0) | 0 (0) | 0.6334 |
| Unknown | 106 (0.6) | 33 (0.5) | 33 (0.5) | 0 (0) | 0 (0) | 1 |
| T stage | ||||||
| T1 | 3823 (21.1) | 1586 (25.2) | 1551 (24.9) | 49 (40.8) | 34 (53.1) | 0.0001 |
| T2 | 5237 (28.9) | 2286 (36.3) | 2271 (36.4) | 27 (22.5) | 14 (21.9) | 0.018 |
| T3 | 2910 (16.1) | 968 (15.4) | 962 (15.4) | 10 (8.3) | 6 (9.4) | 0.223 |
| T4 | 3058 (16.9) | 794 (12.6) | 789 (12.6) | 13 (10.8) | 5 (7.8) | 0.3417 |
| Unknown | 3080 (17) | 672 (10.7) | 667 (10.7) | 21 (17.5) | 5 (7.8) | 0.6818 |
| N stage | ||||||
| N0 | 3711 (20.5) | 864 (13.8) | 854 (13.7) | 20 (33.3) | 11 (34.4) | 0.0026 |
| N1 | 3233 (17.9) | 1136 (18.1) | 1130 (18.1) | 7 (11.7) | 5 (15.6) | 1 |
| N2 | 8725 (48.3) | 3831 (61.1) | 3816 (61.2) | 26 (43.3) | 14 (43.8) | 0.0673 |
| N3 | 920 (5.1) | 291 (4.6) | 289 (4.6) | 5 (8.3) | 2 (6.3) | 0.6591 |
| Unknown | 1486 (8.2) | 151 (2.4) | 151 (2.4) | 2 (3.3) | 0 (0) | 1 |
| M stage | ||||||
| M0 | 16277 (90.1) | 5991 (95.5) | 5959 (95.5) | 58 (96.7) | 31 (96.9) | 1 |
| M1 | 925 (5.1) | 179 (2.9) | 178 (2.9) | 2 (3.3) | 1 (3.1) | 0.6049 |
| Unknown | 873 (4.8) | 103 (1.6) | 103 (1.7) | 0 (0) | 0 (0) | 1 |
| AJCC Stage | ||||||
| I | 989 (5.5) | 202 (3.2) | 187 (3) | 24 (20) | 14 (21.9) | 0.0001 |
| II | 1330 (7.3) | 355 (5.6) | 348 (5.6) | 12 (10) | 7 (10.9) | 0.0908 |
| III | 2851 (15.7) | 1059 (16.8) | 1049 (16.8) | 12 (10) | 10 (15.6) | 1 |
| IV | 10729 (59.3) | 4357 (69.1) | 4327 (69.3) | 54 (45) | 29 (45.3) | 0.0001 |
| Unknown | 2209 (12.2) | 333 (5.3) | 329 (5.3) | 18 (15) | 4 (6.3) | 0.5803 |
| Chronicity | ||||||
| Synchronous | n/a | n/a | n/a | 46 (76.7) | 27 (84.4) | n/a |
| Metachronous | n/a | n/a | n/a | 14 (23.3) | 5 (15.6) | n/a |