Table 3. Institutional HPVmHNSCC Patient characteristics.
17 patients were identified at the University of Pittsburgh and Vanderbilt University with confirmed multiple HPVmHNSCCs. When comparing single vs multiple HPVmHNSCC at the University of Pittsburgh, similar to the SEER data, patients with multiple HPVmHNSCCs were more likely to present with early T stage.
| Pittsburgh Single HPVmHNSCC (n=691) |
Pittsburgh Multiple HPVmHNSCC (n=12) |
Vanderbilt Multiple HPVmHNSCC (n=5) |
Pooled Pittsburgh and Vanderbilt Multiple HPVmHNSCC (n=17) |
Pitt Single vs Multiple HPVmHNSCC p-values |
|
|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | ||
| Sex | |||||
| Male | 600 (86.8) | 9 (75) | 4 (80) | 13 (76.5) | 0.2084 |
| Female | 91 (13.2) | 3 (25) | 1 (20) | 4 (23.5) | 0.2084 |
| Age | |||||
| Mean | 57.4 | 53.8 | 52.6 | 53.8 | 0.1866 |
| Median | 57 | 54.5 | 52 | 52 | n/a |
| Range | 21-90 | 36-69 | 44-61 | 36-69 | n/a |
| Race | |||||
| White | 656 (94.9) | 12 (100) | 5 (100) | 17 (100) | 1 |
| Black | 26 (3.8) | 0 (0) | 0 (0) | 0 (0) | 1 |
| Japanese | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 |
| Other | 2 (0.3) | 0 (0) | 0 (0) | 0 (0) | 1 |
| Unknown | 7 (1) | 0 (0) | 0 (0) | 0 (0) | 1 |
| T Stage | |||||
| T1 | 232 (33.6) | 15 (62.5) | 5 (50) | 20 (58.8) | 0.0072 |
| T2 | 275 (39.8) | 5 (20.8) | 3 (30) | 8 (23.5) | 0.0869 |
| T3 | 65 (9.4) | 1 (4.2) | 1 (10) | 2 (5.9) | 0.7165 |
| T4 | 63 (9.1) | 1 (4.2) | 1 (10) | 2 (5.9) | 0.7145 |
| Unknown | 56 (8.1) | 2 (8.3) | 0 (0) | 2 (5.9) | 1 |
| N stage | |||||
| N0 | 81 (11.7) | 3 (25) | 1 (20) | 4 (23.5) | 0.1637 |
| N1 | 136 (19.7) | 4 (33.3) | 2 (40) | 6 (35.3) | 0.2696 |
| N2 | 439 (63.5) | 5 (41.7) | 2 (40) | 7 (41.2) | 0.1376 |
| N3 | 28 (4.1) | 0 (0) | 0 (0) | 0 (0) | 1 |
| Unknown | 7 (1) | 0 (0) | 0 (0) | 0 (0) | 1 |
| M stage | |||||
| M0 | 658 (95.2) | 12 (100) | 5 (100) | 17 (100) | 1 |
| M1 | 13 (1.9) | 0 (0) | 0 (0) | 0 (0) | 1 |
| Unknown | 20 (2.9) | 0 (0) | 0 (0) | 0 (0) | 1 |
| Chemotherapy | |||||
| Yes | 446 (64.5) | 8 (66.7) | 5 (100) | 13 (76.5) | 1 |
| No/unknown | 245 (35.5) | 4 (33.3) | 0 (0) | 4 (23.5) | 1 |
| Radiotherapy | |||||
| Yes | 585 (84.7) | 10 (83.3) | 4 (80) | 14 (82.4) | 1 |
| No/unknown | 106 (15.3) | 2 (16.7) | 1 (20) | 3 (17.6) | 1 |
| Chronicity | |||||
| Synchronous | n/a | 9 (75) | 3 (60) | 12 (70.6) | n/a |
| Metachronous | n/a | 3 (25) | 2 (40) | 5 (29.4) | n/a |
| Smoking history | |||||
| Yes | 476 (68.9) | 8 (66.7) | 1 (20) | 9 (52.9) | 1 |
| No/unknown | 215 (31.1) | 4 (33.3) | 4 (80) | 8 (47.1) | 1 |