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. 2020 Jan 1;10(1):164–178.

Figure 2.

Figure 2

MY-5445 resensitizes ABCG2-overexpressing human S1-M1-80 colon cancer cells to conventional chemotherapeutic drugs. Drug-sensitive parental human S1 colon cancer cells (left panels) and the ABCG2-overexpressing multidrug-resistant variant S1-M1-80 cancer cells (right panels) were treated with increasing concentrations of (A) mitoxantrone or (B) SN-38 or (C) topotecan in the presence of DMSO (open circles), MY-5445 at 0.5 μM (open squares), 1 μM (filled squares), 2 μM (open triangles) or 3 μM (filled triangles). Points, mean values from at least three independent experiments; bars; SEM.