Figure 3.

MetaCore pathway analysis of the upregulated genes in ER⁺ patients from different public databases. The 501 significantly expressed genes in ER⁺ patients and in the MCF-7-estradiol group that were identified by the Venn diagram analysis were exported to the MetaCore pathway analysis tool to explore potential gene networks and signaling pathways impacted by the selected genes. (A) MetaCore pathway analysis indicated that the amino acid metabolism-related pathway and (B) the L-arginine pathway were significantly associated with ER⁺ patients and the MCF-7-estradiol group.