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. 2020 Jan 1;10(1):148–163.

Figure 2.

Figure 2

Aberrant expression of ADAR1 promotes tumor proliferation in pancreatic cancer. (A-C) Pancreatic cancer cell lines (PANC-1 and BxPC-3) were infected with indicated plasmids. After 72 h, cells were harvested for Western Blotting analysis (A), cell proliferation assay (B) and colony formation assay (C). Data presented as Means ± SD (n = 3). **, P < 0.01; ***, P < 0.001. (D-F) Pancreatic cancer cell lines (PANC-1 and BxPC-3) were transfected with indicated plasmids. 72 h post-transfection, cells were used for Western Blotting analysis (D), cell proliferation assay (E) and colony formation assay (F). Data presented as Means ± SD (n = 3). **, P < 0.01; ***, P < 0.001. (G-J) PANC-1 cells infected with indicated plasmids. After 72 h, the protein level of ADAR1 was analyzed by Western Blotting (G), then cells were injected subcutaneously into the nude mice for xenografts assay for 21 days. The image of xenografts was shown in (H), the tumor mass and volume of xenografts was determined in (I and J). Data presented as Means ± SD (n = 6). ***, P < 0.001.