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. 2020 Jan 1;10(1):38–59.

Figure 5.

Figure 5

Effects of SRSF6-targeted miR-193a-5p on the liver colonization of Panc-1 cells xenografts in mice. (A) Experimental design: immunocompromised mice were injected through tail vein with Panc-1 cells transfected with either the control lentivirus, miR-193a-5p lentivirus, SRSF6 lentivirus, miR-193a-5p lentivirus plus SRSF6 lentivirus, or miR-193a-5p sponge. (B, C) miR-193a-5p levels (B) and SRSF6 protein levels (C) in Panc-1 cells transfected with different lentiviruses. (D, E) Representative BLI images (D) and quantitative analysis of the fluorescence intensities (E) of mice of five groups. The BLI was performed on days 10, 20, and 30 after injection. The intensity of BLI is represented by the color. (F) Upper: Representative liver tissues isolated from the intravenously injected mice. Red arrows indicate metastatic nodules. Lower: Representative H&E staining of liver tissues. (G) Representative H&E staining in lung tissues. Scale bar, 100 μm. All data are shown as the mean ± SEM. ***P<0.001.