MiR-1246 intracellular and extracellular expression increases in a time-dependent pattern after irradiation of NSCLC cells. A. The intracellular miR-1246 response in A549 cells after irradiation (2 Gy) at 24 h according to GSE112375. B. The relative miR-1246 values as determined by microarray (GSE112375). C. Relative intracellular expression of miR-1246 (n=3) in A549 and PC9 cells after irradiation at 24 h, 36 h, and 72 h; levels are assessed by qRT-PCR. D. Extracellular relative expression of miR-1246 (n=3) in A549 and PC9 cells after irradiation at 24 h, 36 h, and 72 h; levels are assessed by qRT-PCR. Data are shown as the mean ± SD. *, P<0.05; **, P<0.01; ***, P<0.001; ns, no significant. IR: irradiation. NIR: non-irradiation.