Table 3. Univariate and multivariate Cox regression analysis of overall survival in ESCC.

Age, pathologic stage, tumor stage, histologic grade and prognostic score were continuous variable. Specifically, pathologic stage: I = 1, II = 2, III = 3, IV = 4; Tumor stage: T1 = 1,T2 = 2, T3 = 3, T4 = 4; Histologic grade: G1 = 1, G2 = 2, G3 = 3.

Variables	Univariate analysis		Multivariate analysis
	Hazard radio (95% CI)	P	Hazard radio (95% CI)	P
Age	1.023 (0.965–1.086)	0.445	1.087 (0.969–1.221)	0.156
Gender (male/female)	0.033 (0.000–4.833)	0.180	0.000 (0.000–Inf)	0.973
Pathologic stage	1.868 (0.982–3.552 )	0.057	7.133 (0.064–79.317)	0.110
Tumor stage	0.869 (0.427–1.768)	0.698	0.206 (0.035–1.218)	0.081
Node stage (N-/N+)	3.105 (1.077–8.953)	0.036	1.043 (0.184–5.908)	0.962
Metastasis stage (M-/M+)	3.431 (0.948–12.413)	0.060	0.004 (0.000–1.544)	0.069
Histologic grade	0.869 (0.418–1.807)	0.707	0.330 (0.088–1.234)	0.099
Prognostic score	1.090 (1.041–1.141)	<0.001	1.091 (1.034–1.15)	0.001