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. 2020 Feb 6;11:100. doi: 10.3389/fimmu.2020.00100

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Copyright © 2020 Boettcher, Li, Ahrens, Kiupel, Byrne, Loving, Cino-Ozuna, Wiarda, Adur, Schultz, Swanson, Snella, Ho, Charley, Kiefer, Cunnick, Putz, Dell'Anna, Jens, Sathe, Goldman, Westin, Dekkers, Ross and Tuggle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T and NK cells are reconstituted after pig to pig bone marrow transplantation. (A) One ART^−/− IL2RG^−/Y SCID piglet underwent a bone marrow transplant at 5 days of age. At five months post transplantation, mononuclear cells were stained for CD3ε, CD172α, CD16, CD79α, and CD21 to assess for donor T (CD3ε⁺), NK (CD3ε⁻ CD16⁺ CD172α⁻), and B cell (CD79α⁺ CD21^+/−) development. (B) Complete blood counts were also performed routinely, and white blood cell counts increased upon every collection point. CBC data shown for up to 4 months post BMT.