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. 2020 Feb 3;10:51. doi: 10.3389/fonc.2020.00051

Figure 1.

Figure 1

Genetic alterations of kynurenine pathway components in SKCM and other cancer types from TCGA dataset (cBioPortal). (A) The kynurenine pathway of tryptophan catabolism, (B) Frequency of genetic alterations in any of the kynurenine pathway enzymes, and (C) genetic alterations of genes encoding enzymes IDO1, IDO2, TDO2, KYNU, KMO, KATs (CCBL1, CCBL2, GOT2, and AADAT), HAAO, ACMSD, and QPRT for top 10 tumor types. DNA amplification (red), mutation (green), and deletion (blue) (D), Kaplan–Meier survival plots for KATs alteration in 287 SKCM samples.