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. 2020 Feb 3;10:51. doi: 10.3389/fonc.2020.00051

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Copyright © 2020 Rad Pour, Morikawa, Kiani, Gomez-Cabrero, Hayes, Zheng, Pernemalm, Lehtiö, Mole, Hansson, Eriksson and Tegnér.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kynurenine metabolites in plasma of CMM (PRE&TRM) compare to healthy controls. (A) The concentrations of KYN, TRP and (B) KYNA, 3-HK, AA, 3HAA, and XA were determined on plasma samples derived from healthy volunteers (HC, n = 5) and metastatic CMM patients, before (PRE) and during the first treatment (TRM) with MAPKIs (n = 5). TRP, tryptophan; KYN, L-kynurenine; KYNA, kynurenic acid; AA, anthranilic acid; 3-HK, 3-hydroxykynurenine; 3HAA, 3-hydroxyanthranylic acid; XA, xanthurenic acid; CMM, cutaneous; UM, Unknown Melanoma. **p < 0.005; Corrected P-Values (Bonferroni).