Table 2.

Kynurenine metabolites in plasma of CMM (PRE&TRM) compare to healthy controls.

	Healthy control (n = 5)	95% IC	PRE (mean n = 5)	95% IC	Corrected P-value (healthy vs. PRE)	TRM (mean n = 5)	95% IC	Corrected P-value (PRE vs. TRM)
TRP (uM)	42.04	35.9–48.2	45.4	34.0–58.7	>0.9999	42.98	31.2–54.7	>0.9999
KYN (uM)	2.66	2.1–3.3	3.54	1.8–5.2	>0.9999	9.78	6.6–12.9	0.9374
KYNA (nM)	38.11	26.0–50.2	43.45	24.0–55.1	0.9880	27.57	19.8–35.4	0.9051
3-HK (nM)	195.30	162.6–228.0	73.23	21.9–111.2	<0.001**	324.9	295.6–354.2	<0.001**
3HAA (nM)	372.28	360.3–384.3	147.96	77.9–218.0	<0.001**	804.47	751.2–857.8	<0.001**
AA (nM)	23.10	17.9–28.3	28,51	13.1–40.5	0.3793	43.85	35.4–52.3	0.7467
XA (nM)	73.51	52.0–95.0	57.23	25.8–77.8	0.5776	88.51	62.1–115.0	0.3203

TRP, tryptophan; KYN, L-kynurenine; KYNA, kynurenic acid; AA, anthranilic acid; 3-HK, 3-hydroxykynurenine; 3HAA, 3-hydroxyanthranylic acid; XA, xanthurenic acid (XA); CMM, coutenous; UM, Unknown Melanoma.

^**p < 0.005; Corrected P-Values (Bonferroni).